Hepatitis C Screening, Prevalence and Drug Effectiveness
Hepatitis C is a liver disease caused by infection with the hepatitis C virus. Severity can range from a mild illness lasting a few weeks to a lifelong serious illness. Hepatitis C is usually spread when blood from a person infected with the hepatitis C virus enters the body of someone who is not infected. Many people with hepatitis C virus do not know they are infected, so efforts are underway to increase rates of screening so that people can be treated.
Screening and prevalence for Veterans in VA care
Hepatitis C screening and infection rates for Veterans who received VA care in calendar year (CY) 2012 and in (CY) 2013 were significantly higher for Veterans born from 1945-65 than those born in other periods.
- American Journal of Public Health 2014: Impact of Race/Ethnicity and Gender on HCV Screening and Prevalence Among U.S. Veterans in Department of Veterans Affairs Care
- Journal of the American Medicine Association (JAMA) IM Research Letter CY 2013 Rates of Hepatitis C Virus Testing in VA
Effectiveness of sofosbuvir-based therapy
This project describes the sustained virologic response in Veteran’s starting SOF-based therapy in 2014.
- Effectiveness of sofosbuvir-based regimens in genotype 1 and 2 hepatitis C virus infection in 4026 U.S. Veterans
Population Approach to Direct Acting Antivirals
This project describes the comprehensive program established by VA to oversee the use of the new direct-acting antivirals.
- A Population Approach to Disease Management: Hepatitis C Direct-Acting Antiviral Use in a Large Health Care System
This program includes critical analysis of the differences between clinical efficacy observed in clinical trials and clinical effectiveness observed in clinical practice.
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